Flubendazole and Other Microtubule Disrupters
Flubendazole Flubendazole is an anthelmintic, used both in humans and for veterinarian purposes. It is very close chemically to mebendazole, the only difference being an added fluorine group.[2] Human use It is available for human use to treat worm infections. In certain countries such as France, it is inexpensive and available OTC (without prescription)[3] under the brand name Fluvermal as an alternative to mebendazole which is not currently sold there.[4] Under veterinary use, its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.[5] The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma ( 2010 ) On-patent and off-patent drugs with previously unrecognized anticancer activity could be ra...