My Longevity Journey

  Longevity:   In ITP, curcumin extended genetically-heterogeneous mice lifespan by 3.69% ( link ), but this result wasn’t statistically significant. Mice lifespan +10% (p < 0.01) in another study. ( ref )   Metabolic effects:   Lowers chronic inflammation. C-reactive protein (−1.55 mg/L; −1.81 to −1.30), IL6 (−1.69 pg/mL, −2.56 to −0.82), tumor necrosis factor α (−3.13 pg/mL; −4.62 to −1.64), IL-8 (−0.54 pg/mL; −0.82 to −0.28), and an increase in IL-10 (0.49 pg/mL; 0.10 to 0.88) ( ref ) Increases total antioxidant capacity. A significant increase of SOD activities (WMD: 1.46 U/mL, 95%CI: 0.60–2.32, p = 0.0009),  significantly reduced serum lipid peroxides (WMD: −6.35 nmol/mL, 95%CI: −11.06 to −1.64, p = 0.008), increased GSH concentrations (WMD: 5.39 µg/mL, 95%CI: 1.17–9.60, p = 0.01), and catalase activity (WMD: 51.78 U/mL, 95%CI: 15.71–87.85, p = 0.005) ( ref ) Helps with weight loss. Significantly reduced body mass index (BMI) (SMD −0.37; 95% CI, −0.61, −0.13; P < 0.01),

  Inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells Promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism. Resveratrol inhibited proliferation and induced apoptosis in JAK2(V617F) mutant tumor cells and its selectivity was 1.5-6.9 times greater than that observed in other tumor cells without the JAK2(V617F) mutation. Improves health and survival of mice on a high-calorie diet, 2016. All cause mortality HR=0.69 (p=0.02) .  Extended the lifespan of diverse species including Saccharomyces cerevisiae, C elegans and Drosophila melanogaster.  ITP testing found 4% median life extension in biologically diverse mice ( link ).   Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies Treatment of ACHN and A498 renal carcinoma cells with RSV resulted in significantly impaired cell growth, cell-to-cell contact, and migration. RSV treatment