My Longevity Journey

  In RCTs, a decreased risk of all cause mortality was seen with antioxidant mixtures when selenium was part of the mix  (RR: 0.90; 95% CI: 0.82, 0.98; P = 0.02). A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in inflammatory markers such as serum IL-1, IL-6, TNF-α, and IFN-γ levels (P < 0.05). Improved lipid profile of healthy volunteers. Selenium supplementation decreased serum CRP (SMD = −0.48; 95% CI, −0.96 to 0; p = 0.049) and increased glutathione peroxidase (SMD = 0.5; 95% CI, 0.36–0.64; p < 0.001). Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice. Selenium supplementation mitigates the toxic effects of environmental mercury, lead, arsenic, and cadmium by forming an insoluble complex (chelate) with these metals and reversing the oxidative damage. Selenium supplementation improved semen parameters in males. 2 Brazil nuts per day provide optimal intake (there is ~96 µg of

  The most effective anti-aging intervention in mice. mTOR inhibitor + STAT3 inhibitor. Potent inducer of autophagy. Antimetastasis & anti-cancer in RCC. Effective against myeloproliferative neoplasms.  Cream improves aged human skin.  Rapamycin is an effective inhibitor of human renal cancer metastasis, 2003 Rapamycin reduced the number of pulmonary metastases. Circulating levels of VEGF-A and TGF-beta1 were lower in the rapamycin-treated mice compared to untreated or cyclosporine-treated mice. Rapamycin may be of value for patients with RCC and that its antitumor efficacy is realized by cell cycle arrest and targeted reduction of VEGF-A and TGF-beta1.  Newly Approved mTOR Inhibitors for the Treatment of Metastatic Renal Cell Carcinoma ( 2009 ) The mammalian target of rapamycin (mtor) is an important target in the treatment of RCC. In first-line treatment for patients with disease having poor prognostic features, temsirolimus, an mtor inhibitor, has demonstrated benefit over inter