What are the best treatments for PV today?
What are the most promising treatments for PV / MPN today? COMBINE PHLEBOTOMY AND ASPIRIN In Polycythemia Vera (PV), an increased red blood cell mass raises the risk of thrombosis and cardiovascular death. Reducing the risk of blood clots (thrombosis) can be achieved by taking aspirin and maintaining hematocrit levels within the range recommended by your physician (<45 or <42). Phlebotomy: The study , conducted by Marchioli et al., examined the effects of different treatment intensities in patients with JAK2-positive polycythemia vera. A total of 365 adults were randomly assigned to receive either more intensive treatment (target hematocrit <45%) or less intensive treatment (target hematocrit 45-50%). The study concluded that patients with a hematocrit target of less than 45% had significantly lower rates of cardiovascular death and major thrombosis than those with a hematocrit target of 45-50%. Aspirin: A double-blind, placebo-controlled, randomized trial involving 518 p