My Longevity Journey

  Coffee: In a retrospective analysis, those who drank 4–5 cups of coffee per day had a 12-16% reduced risk of early death in the following 12–13-years. 1 cup per day was associated with a 5–6% lowered risk of early death. In an RCT with 500ml coffee consumption per day, DNA strand breaks in the coffee group decreased in comparison to the control group:  − 23% in the coffee group (p = 0.0012). Coffee has the greatest antioxidant capacity among the commonly consumed beverages (>=100mg CGA in a cup). Green coffee bean is rich in chlorogenic acid (CGA) and its related compounds (50% CGA).  Increases autophagy across liver, muscle, heart in mice experiments via inhibition of mTOR and global deacetylation of cellular protein. Green Coffee Bean Extract: After 28 days, systolic blood pressure (SBP) in the placebo, 46 mg, 93 mg, and 185mg GCBE groups was reduced by −1.3±3.0 mmHg, −3.2±4.6 mmHg, −4.7±4.5 mmHg, and −5.6±4.2 mmHg from the baseline, respectively.  Diastolic blood pressure

  The body makes a chemical called acetylcholine from phosphatidylcholine. Acetylcholine is important for memory and other functions in the body. Phosphatidylcholine might help to protect the liver and the wall of the large intestine. Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia, 2020 A total of 2843 adult patients with newly diagnosed NAFLD, who had a least one of four comorbidities, namely, overweight/obesity, hypertension, type 2 diabetes mellitus, and hypercholesterolaemia, and who were prescribed 1.8 g/day of PPC as an adjunctive treatment to standard care, were enrolled during 2015–2016. Laboratory data were collected at baseline and 12 and 24 weeks of the study, and included liver function tests (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT)), fasting plasma g