Ergothioneine
The Magic of Longevity Mushrooms: Ergothioneine’s Remarkable Impact on Lifespan and Cognitive Enhancement ( 2024 ) Japanese scientists show that treating male mice with ergothioneine, a compound found in Lion's Mane in high concentrations, significantly extends the median and average lifespan by 16% and 21%, respectively. Supplementing male mice with ergothioneine (ERGO) increases the median and average lifespan by 16% and 21%, respectively. ERGO supplementation enhances learning and memory. Ergothioneine from mushrooms extends mouse lifespan ( video ) Ergothioneine, an amino acid abundant in mushrooms, increased lifespan in male mice when supplemented at 4-5 mg/kg/day starting at 7 weeks old. Median lifespan increased by 16%, average by 21%, and maximum (when 90% died) by 29% with ergothioneine treatment. However, control lifespan was shorter than historical norms, possibly due to the low ergothioneine chow they received. Ergothioneine also extended lifespan in a dose-dependent