Inositol / IP6
Longevity: Extended the lifespan of C Elegans by activating daf-18 (Pten). Alters lifespan via mitophagy regulator PTEN induced kinase-1 (pink-1) and mitophagy. Promotes mouse healthspan ( ref ). Extended the lifespan of fruit fly through anti-oxidant and other effects. ( ref ) Metabolic effects: Myo-inositol is a vitamin-like compound that cells in the body require to generate energy and burn fat. Uses cases: Ref . Inositol supplementation decreased blood glucose through an improvement in insulin sensitivity that is independent of weight. HOMA-IR (MD −1.96 mmol × mUI/l, 95% CI −2.62, −1.30). ( ref ) Supplementation significantly decreased SBP and DBP. SBP (WMD − 5.69 mmHg; 95% CI − 7.35 to − 4.02, P < 0.001) and DBP (WMD − 7.12 mmHg; 95% CI − 10.18 to − 4.05, P < 0.001). ( ref ) Supplementation significantly decreased BMI (WMD = −0.41 kg/m2; 95% CI: −0.78, −0.04; p = 0.028). ( ref ) in vitro, IP6 reduced the formation of advanced glycation end-products (AGEs) . T2D who ...