My Longevity Journey

  What are the most promising treatments for PV / MPN today? COMBINE PHLEBOTOMY AND ASPIRIN In Polycythemia Vera (PV), an increased red blood cell mass raises the risk of thrombosis and cardiovascular death. Reducing the risk of blood clots (thrombosis) can be achieved by taking aspirin and maintaining hematocrit levels within the range recommended by your physician (<45 or <42).  Phlebotomy: The study , conducted by Marchioli et al., examined the effects of different treatment intensities in patients with JAK2-positive polycythemia vera. A total of 365 adults were randomly assigned to receive either more intensive treatment (target hematocrit <45%) or less intensive treatment (target hematocrit 45-50%). The study concluded that patients with a hematocrit target of less than 45% had significantly lower rates of cardiovascular death and major thrombosis than those with a hematocrit target of 45-50%. Aspirin: A double-blind, placebo-controlled, randomized trial involv...

  A SHORT SUMMARY OF LONGEVITY INTERVENTIONS How to select which intervention to bet on? We’ll look for the following evidence to come up with a strategy: [Longer human lifespan] Drugs/supplements/lifestyle changes that were shown to lower all cause mortality in long-running human RCTs (Randomized Clinical Trials) — the gold standard in research. Additionally, we will consider interventions that are associated with increased human longevity, though the evidence from RCTs might be still emerging.  [Longer mice lifespan with some supporting evidence from humans] Drugs/supplements/lifestyle changes that extended mice lifespan with promising outcomes in short-term human RCTs (~causation) or retrospective analyses (~association).  [Treat based on biomarkers] Treat high/low values in your labs and biomarkers (e.g. optimize when they aren’t in the ideal range).  [Track your N=1] Don’t blindly follow statistics; make sure the drug/supplement you’re taking works for you spe...