Leukotriene Inhibitors
GENERAL SUMMARY: Leukotriene inhibitors are medications that block inflammatory substances called leukotrienes, helping to alleviate and prevent asthma symptoms and allergic reactions. Recent studies suggest potential benefits of leukotriene inhibitors in conditions such as cancer, obesity-related inflammation, diabetes, heart disease, and neurological aging. ANTI-CANCER EFFECTS: LTRA (Cysteinyl Leukotriene Receptor Antagonists) use in asthma patients from Taiwan demonstrated a dose-dependent decrease in cancer risk across all cancers studied, warranting further study of their chemopreventive potential ( 2016 ). LTRA use in Korea was associated with a decreased cancer risk, especially when used in high doses and for longer durations ( 2022 ). In a 2017 study, arachidonate 5-lipoxygenase (Alox5) was found to be a key genetic effector of JAK2V617F in driving Polycythemia Vera (PV), while combining 5-lipoxygenase (5-LOX) inhibitor zileuton with JAK2 inhibitor ruxolitinib demo...