Alpha Ketoglutarate (AKG)
GENERAL EFFECTS: An important Krebs cycle intermediate and precursor for amino acids like glutamine and glutamate. Acts as a cofactor for enzymes involved in epigenetic regulation, ammonia detox, kidney health, bone health, hypoxia sensing etc ( ref , ref , ref , ref ). Extended life span in worms, fruit flies and mice, and promoted healthy aging in mice ( 2020 ). Calcium Alpha-Ketoglutarate Supplementation Reduced Epigenetic Age in Humans by 8.5 years ( 2021 ). EFFECTS ON CANCER & COVID-19: Supplementation mitigates metabolic disturbances in MPNs , reduces symptoms in mice such as splenomegaly and elevated platelets, and shows potential as a therapeutic agent for platelet hyperreactivity ( 2022 ). Inhibits Akt-mediated activation in platelets and monocytes, reducing clot formation and inflammation, and alleviates COVID-19 effects in lungs ( 2021 ). Improved the efficacy of anti-PD1 melanoma treatment through epigenetic modulation of PD-L1 ( 2023 ) Elevated intr...