My Longevity Journey

  Extended male mice lifespan significantly in ITP ( ref ). Alleviated NASH in humans. (a) Representative H&E-stained liver sections from two subjects with NASH before and after treatment revealed that astaxanthin improved steatohepatitis after 24 weeks of treatment. (b) NAFLD activity score (NAS) in NASH subjects dropped on astaxanthin (AX, n = 7). P < 0.05 vs. pretreatment. Lowered HS-CRP by 0.528 mg/l (P < 0.05) and decreased a DNA damage biomarker. Increased HDL-C marginally (WMD: 1.473 mg/dl, p = 0.012).  Reduced Diastolic BP by 2.77 mmHg (95 %CI: −4.34, −1.19). Significantly reduced blood malondialdehyde and IL-6 in T2DM patients. Significantly restored skin moisture content (p = 0.03), improved elasticity (p = 0.009) but marginally decreased wrinkle depth (p = 0.11) compared to placebo. Impact of astaxanthin supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials, 2021 This systematic review and meta-analysis on...

  Inflammation: Abnormal expression and activity of a number of proinflammatory cytokines are implicated in MPNs ( ref ):  IL-1β, TNF-α, IL-6, IL-8 , VEGF, PDGF, TGF-β and IFNs.  Chronic inflammation may be an important driving force for clonal evolution and disease progression in MPNs.  Tumor necrosis factor (TNFα) , may underlie malignant clonal dominance in MPN based on results from mouse models. ( ref ) In MF, bone marrow fibrosis itself is thought to be mediated heavily by the cytokine TGF-β , and possibly other cytokines produced as a result of hyperactivated JAK2 kinase in the malignant clone. ( ref ) Treatment of MF with the TGF-β 1/3 Inhibitor AVID200 (MPN-RC 118) ( ref ) Successful case report of controlling MF via TGF-β inhibiting supplements ( ref ) Successful MPN treatments (INF-alpha, Ruxolitinib, Aspirin, Statins etc) also tend to be powerful anti-inflammatories. Oxidation: Reactive oxygen species (ROS) have a major role in carcinogenesis and disease p...