My Longevity Journey

Proteolysis, the enzymatic breakdown of proteins, is vital for cellular health and function. Its decline is linked to several age-related issues. A primary effect is the loss of muscle mass, or sarcopenia, which occurs as damaged proteins in muscle cells accumulate due to reduced proteolytic activity. This leads to muscle weakness and loss ( Source 1 , Source 2 ). Decreased proteolytic activity also contributes to protein aggregation in neurodegenerative diseases like Alzheimer’s, characterized by the buildup of misfolded proteins. Normally, these proteins are degraded by proteolytic enzymes. A reduction in this activity results in the formation of plaques typical of various neurodegenerative diseases ( Source 1 , Source 2 ). Additionally, impaired cellular function can stem from a reduction in proteolytic activity with age. Proteolysis is crucial for degrading damaged or obsolete proteins, maintaining cellular balance. When this function declines, protein buildup impairs cellular oper...

  L-carnitine is one of the key nutrients for proper mitochondrial function. It helps cellular energy production by transporting fatty acids into the mitochondria and acting as an ROS scavenger. It plays a major part in protecting cellular membranes, preventing fatty acid accumulation and in the elimination of toxic metabolites ( 2022 ). Resulted in minor reductions in body weight, BMI, and fat mass compared to controls ( 2020 ). Strong anti-inflammatory effects (HS-CRP, IL-6, TNF-α) ( 2020 ) Interleukin 6 (IL-6) (WMD: -1.87; 95% CI: -2.80, -0.95) Tumor necrosis factor-α (TNF-α) levels (WMD: -1.43; 95% CI: -2.03, -0.84) C-reactive protein (CRP) (WMD: -0.10; 95% CI: -0.14, -0.06) Impacts blood lipids favorably ( 2019 ) TC (56 arms-MD: -8.53 mg/dl, 95% CI: -13.46, -3.6, I2: 93%) Low-density lipoprotein-cholesterol (LDL-C) (47 arms-MD: -5.48 mg/dl, 95% CI: -8.49, -2.47, I2: 94.5) Triglyceride (TG) (56 arms-MD: -9.44 mg/dl, 95% CI: -16.02, -2.87, I2: 91.8).  High density lipoprote...