Royal Jelly / Propolis

 

Royal Jelly / Propolis

• RJ extended the average mice lifespan by about 25% compared to the control group.

• Epigenetic programming (via bee propolis) makes bees and ants live many times longer. It's very interesting. (video)

• Increased RBC and Hematocrit after 6 months (+0.9%).

Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage, 2003

In this study, we investigate the effect of dietary Royal Jelly (RJ) on tissue DNA oxidative damage and on the life span of C3H/HeJ mice. In C3H/HeJ mice that were fed a dietary supplement of RJ for 16 weeks, the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, were significantly reduced in kidney DNA and serum. Secondly, we determined the effect of dietary RJ on the life span in C3H/HeJ mice. The 50% mice survivals of intermediate- (about 6 mg/kg weight) and high-dose groups (about 60 mg/kg weight) were reached at significantly longer times than that of the control group according to the generalized Wilcoxon test (p<0.05). The average survival times were 88 weeks for the control group vs. 79 weeks for the low-dose group (about 0.6 mg/kg weight), 112 weeks for the intermediate-dose group and 110 weeks for the high-dose group, respectively, showing that RJ extended the average survival time by about 25% compared to the control group. However, RJ did not extend the total life span. These results indicated that dietary RJ increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage.

The effect of short-term royal jelly supplement on testosterone levels in sedentary and healthy individuals, 2020

This study with a placebo-controlled experimental design intends to investigate the effect of Royal Jelly (RJ) on the testosterone levels in sedentary men at a dose of 1000 mg/day. For this purpose, a total of 20 adult sedentary men aged 21 to 23 were included in this study. The subjects visited the laboratory every day for 15 days between 08:00 and 10:00 to get their portion of royal jelly. The subjects were randomly divided into two groups, namely the experimental group (n = 10 individuals, 1000 mg/day of Royal Jelly) and the placebo group (n = 10 individuals, corn starch mixed with 1000 mg/day of water) and they took royal jelly in glass vials at the same time. Blood samples were taken from both groups of subjects one day before and one day after the study and analyzed to determine their testosterone levels. 2x2 mixed factor ANOVA and LSD tests were used to analyze data obtained from the experimental and the placebo group. A sharp increase in the testosterone levels of the experimental group that took RJ for a short time was found to be statistically significant (p<0.05). The pre- and post-test values of the placebo group were not found to be statistically significant (p>0.05). The study shows that a 1000 mg/day dose of RJ supplements was effective in increasing testosterone levels in sedentary, healthy men.

Effect of royal jelly ingestion for six months on healthy volunteers, 2012

We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.

Results

Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).

Conclusions

Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

Oral intake of royal jelly has protective effects against tyrosine kinase inhibitor-induced toxicity in patients with renal cell carcinoma: A randomized, double-blinded, placebo-controlled trial. Medicines, 2018

Although tyrosine kinase inhibitors (TKIs) are still recommended as the standard therapy in renal cell carcinoma (RCC), the high frequency of adverse events is a weakness of this therapy. Because royal jelly (RJ) possesses anti-inflammatory and antioxidant properties, we assessed its protective effects on TKI-induced toxicities in RCC patients. Methods: We enrolled 33 patients with advanced RCC who were assigned to start TKI therapy in combination with a randomized, double-blinded, placebo-controlled RJ trial consisting of a placebo group with 17 subjects and an RJ group with 16 subjects. Results: Fatigue and anorexia frequencies in the RJ group were significantly lower than in the placebo group (p = 0.003 and 0.015, respectively). A statistically significant correlation between RJ and fatigue or anorexia was detected in sunitinib-treated patients. The dose reduction- or discontinuation-free periods were significantly longer (p = 0.013) in the RJ group than in the placebo group. Furthermore, similar observations were made in sunitinib-treated patients (p = 0.016). Conclusions: Our clinical trial showed that RJ exerted protective effects against TKI-induced fatigue and anorexia and lowered TKI dose reduction or discontinuation. Hence, RJ is beneficial for maintaining the quality of life and medication compliance in TKI-treated RCC patients.

My husbands previous dr had recommended RJ What dosage does your husband take?

1000mg a day, and 40 mg propolis in this compound

Royal jelly is an effective and relatively safe alternative approach to blood lipid modulation: A meta-analysis

The role of royal jelly on blood lipid profiles was assessed by a meta-analysis.

Royal jelly can reduce total cholesterol (TC) blood levels.

No significant change was observed in triglyceride, LDL-C and HDL-C blood levels.

Greater impact on TC was observed in subgroup with more than 90 days intervention.

Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic review

Diabetes mellitus is one of the most common endocrine disorders in the world. This systematic review was conducted with focus on the current knowledge on the effect of royal jelly on metabolic variables in diabetes mellitus. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched from inception until June 2018. All clinical trials and animal studies that evaluated the effects of royal jelly on diabetes mellitus, and were published in English-language journals were eligible. Studies that provided insufficient outcomes were excluded. Out of 522 articles found in the search, only twelve articles were eligible for analysis. Seven studies showed a significant reduction in FBS, and one reported HbA1c decrease following royal jelly supplementation. Although royal jelly supplementation resulted in significant reductions in HOMA-I R in three studies, the findings on insulin levels were controversial. In addition, royal jelly substantially improved serum levels of triglycerides, cholesterol, HDL, LDL, VLDL and Apo-A1 in diabetes mellitus. In addition, royal jelly resulted in a decrease oxidative stress indicators and increase antioxidant enzymes levels. In conclusion, royal jelly could improve glycemic status, lipid profiles and oxidative stress in diabetes mellitus. However, exploring the underlying mechanisms warrants further studies.