Ibuprofen
Multi-species lifespan extension ( 2014 ): Yeast: 17% increase in replicative lifespan with 0.2 mM ibuprofe. Nematodes (C. elegans): 12% increase in mean lifespan with 0.1 mM ibuprofen. Fruit flies (D. melanogaster): 17% increase in mean lifespan for females with 0.5 μM ibuprofen. Suggests a conserved pro-longevity mechanism across evolutionarily divergent species. Protective associations against multiple cancer types ( 2024 umbrella review): Overall NSAID use associated with reduced risk in 8 cancer types. Aspirin use associated with reduced risk in 12 cancer types. Non-aspirin NSAID use (including ibuprofen) associated with reduced risk in 5 cancer types. Cancer prevention may contribute to increased lifespan. Anti-inflammatory and pro-resolving effects ( 2022 ): Ibuprofen modulates inflammatory pathways and promotes resolution of inflammation. Chronic inflammation is associated with accelerated aging and age-related diseases. By reducing inflammation, ibuprofen may slow the aging