My Longevity Journey

  Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells, 2017 Fisetin induced up-regulation of CHOP expression and reactive oxygen species production, which had no effect on fisetin-induced apoptosis. Taken together, our study demonstrates that fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level. Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9, 2019  Fisetin inhibits proliferation and metastasis of RCC cells by downregulating CTSS and ADAM9 through the MEK/ERK signaling pathway. These findings indicate that fisetin is a promising antitumor agent against RCC. Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients A growing body of evidence indicates that inflammation is associated with tumorigenesis, metastas...

  Inhibits JAK/STAT3 Signaling and Growth of Renal Cell Carcinoma . inhibited tumor formation in various types of cancer cells, including breast cancer, leukemia, Burkitt lymphoma, liver cancer, stomach cancer, gallbladder cancer . Shown to activate hepcidin pathways, through STAT3 activation.  Activates SIRT6 that is responsible for repairing DNA damage .  Extends mice lifespan by +8% .  May enhance libido . A weak PDE5 inhibitor . improved erectile function. May produce Cytochrome P450 drug interactions in a dose-dependent manner. Icariin, a natural flavonol glycoside, extends healthspan in mice [It’s the PARPs and sirtuins ( particularly SIRT6 ) that are responsible for repairing DNA damage. Best way to upregulate those is NMN and Icariin.] So far, the compounds that can specifically regulate the activity of SIRT6 in CVDs are still limited. The Chinese herbal medicine, icariin, widely used in eastern countries to treat specific age-related diseases, including CV...