My Longevity Journey

In patients with T2D, reduced FBS and HbA1c and improved insulin resistance indices such as fasted insulin, HOMA-IR and QUICKI. Anti-oxidant . Protected mice against high doses of radiation that cause massive DNA damage, lipid oxidation, and other cellular damage. Improves mitochondrial health by increasing mitochondrial biogenesis (creation of new mitochondria) ( R , R ). The older we get, the fewer proper functioning mitochondria we have.  Effective in controlling the extent of colorectal, gastric, ovarian, liver, skin, breast, and prostate cancers . Extended lifespan in C elegans , and brought about various longevity-promoting effects ( R ). Stress resistance was increased, while lipofuscin levels were reduced. Lipofuscin is called the “aging pigment”: it accumulates during aging until it’s so ubiquitous it hinders the functioning of cells, especially in long-lived cells like neurons.  Ginger Extract (Gingerenone A) Shows Strong Senolytic Effect. This compound could be s...

  In a human RCT, consuming 500 mg/d cocoa flavanols, including 80 mg epicatechins, resulted in -11% all-cause mortality (95% CI, 0.77, 1.03), -27% CVD death   (95% CI, 0.54, 0.98) after 3.6 yrs follow up.  Insulin resistance ( HOMA-IR: −0.67 ; 95% CI: −0.98, −0.36) was improved by chocolate or cocoa due to significant reductions in serum insulin . Flow-mediated dilatation (FMD) improved after chronic (1.34%; 95% CI: 1.00%, 1.68%) and acute (3.19%; 95% CI: 2.04%, 4.33%) intakes. Reductions in diastolic blood pressure (BP; −1.60 mm Hg ; 95% CI: −2.77, −0.43 mm Hg). Around 5-8% lifespan extension in mice . Chocolate consumption conferred reduced risks of mortality from all causes, cardiovascular disease, and Alzheimer’s disease in a US population. Effect of cocoa flavanol supplementation for prevention of cardiovascular disease events: The COSMOS randomized clinical trial, 2022 Objectives We examined whether cocoa extract supplementation decreases total cardiovascular dis...

  Improves anti-oxidant status — goes very well with NAC. Does this in a way different from vitamins (doesn’t force cells to pick up or make antioxidants; rather antioxidants are made on-demand as much as a cell need)  Reduces glucose AUC & HA1C when given with a high carb meal. Improved mice lifespan by 4.7% in ITP, by 28% in an earlier study.  Glycine supplementation attenuates NAFLD in mice by stimulating hepatic fatty acid oxidation and glutathione synthesis. Reduced platelet aggregation and increased bleeding time. Improves sleep quality .  Increases HGH when taken at high doses. Glycine supplementation extends lifespan of male and female mice, 2019 Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and...