My Longevity Journey

  AKG supplement from double wood : Life changer. Half a capsule in the morning on days I feel really down. My MPN specialist is ok with me taking it. Fairly natural molecule. Scientific Reference:   https://ashpublications.org/blood/article/140/Supplement%201/1095/492376/Transcriptional-and-Metabolic-Profiling-Reveals How does it work? It works by calming down overactive platelets and inflammation. You'll feel a burst of energy if you take it in the morning all day. Suja Uber greens juice or any cucumber/celery juice : Pretty good boost to energy. Too much might cause a burn out. Just half a bottle is enough. Scientific Reference:   I cannot explain why celery juice and/or cucumbers are energizing but they are, and they're very safe. No brainer to try. Green tea and hibiscus tea in the morning : Improves mood / lifts up depression. I drink both everyday. Doesn't give energy. But improves energy by improving mood. Scientific Reference:   Green tea and ...

Amongst natural compounds that inhibit JAK2/STAT3, curcumin stands out as the most promising. Studies consistently demonstrate curcumin's inhibition of JAK2/STAT3 in models ranging from cancer to inflammation. Though typical anti-inflammatory doses of curcumin range from 500-1000 mg daily, some patients with advanced MF report success with larger doses up to 4 grams per day under medical supervision. MPN: Induced apoptosis and inhibited proliferation in myeloproliferative neoplasms by blocking JAK2/STAT and mTORC1 ( Petiti et al., 2019 ) Myelofibrosis: Successful case report of treating MF with high dose Curcumin and COX2 inhibition ( Maccio et al, 2014 ). Lung cancer: Inhibited JAK2/STAT3 signaling, reducing stem-like traits of lung cancer cells ( Wu et al., 2015 ) Neuropathic pain: Downregulated spinal IL-1β via suppressing JAK2-STAT3 signaling ( Liu et al., 2016 ). Squamous cell carcinoma: Suppressed invasion and vasculogenic mimicry via inhibiting JAK-2/STAT-3 signaling ( Hu et...

Daily consumption of hot green tea or its extract, epigallocatechin-3-gallate (EGCG), has been reported to inhibit JAK/STAT pathway across multiple blood cancers and autoimmune conditions. A 2018 study found that EGCG reduces JAK2 expression in chronic myeloid leukemia (CML) cells. EGCG supplementation induced complete molecular remission in a chronic lymphocytic leukemia case ( 2015 ). Furthermore, EGCG has been found to inhibit specific IFN-γ pathways and JAK2 in alopecia areata patients (an autoimmune disorder that causes hair loss) ( 2018 ). It also demonstrated potential in vitiligo (an autoimmune skin condition) treatment by inhibiting JAK2 activity ( 2015 ). Green tea reduced obesity associated inflammation by inhibiting JAK2/STAT3 in mice ( 2020 ). A 2020 study investigated the effects of green tea (GT) consumption on patients with indolent low-grade B-cell lymphomas and leukemias (LGBCL) and monoclonal gammopathy of undetermined significance (MGUS). The authors were inspired...