Curcumin to Inhibit JAK2

Amongst natural compounds that inhibit JAK2/STAT3, curcumin stands out as the most promising. Studies consistently demonstrate curcumin's inhibition of JAK2/STAT3 in models ranging from cancer to inflammation. Though typical anti-inflammatory doses of curcumin range from 500-1000 mg daily, some patients with advanced MF report success with larger doses up to 4 grams per day under medical supervision.


  • MPN: Induced apoptosis and inhibited proliferation in myeloproliferative neoplasms by blocking JAK2/STAT and mTORC1 (Petiti et al., 2019)

  • Myelofibrosis: Successful case report of treating MF with high dose Curcumin and COX2 inhibition (Maccio et al, 2014).

  • Lung cancer: Inhibited JAK2/STAT3 signaling, reducing stem-like traits of lung cancer cells (Wu et al., 2015)

  • Neuropathic pain: Downregulated spinal IL-1β via suppressing JAK2-STAT3 signaling (Liu et al., 2016).

  • Squamous cell carcinoma: Suppressed invasion and vasculogenic mimicry via inhibiting JAK-2/STAT-3 signaling (Hu et al., 2018).

  • Osteosarcoma: Inhibited proliferation and invasion by inactivating JAK2/STAT3 signaling (Sun et al., 2019).

  • Inflammatory conditions: Modulated pain and inflammation through inhibiting JAK2/STAT3 signaling (Uddin et al., 2021).

  • Septic acute kidney injury: Attenuated inflammation and apoptosis through inhibiting NF-κB and JAK2/STAT3 signaling (Zhu et al, 2020).

  • Pancreatitis: Protected against injury by suppressing JAK2/STAT3 signaling in pancreatitis (Zhu et al., 2017).

  • Autoimmune encephalomyelitis: Inhibited microglial inflammation by regulating AXL/JAK2/STAT3 signaling (Sun et al., 2022).

  • Multiple Myeloma: Inhibited Stat3 by 69% in blood mononuclear cells (Vadhan-Raj et al, 2007).

  • Esophageal cancer: Induced apoptosis by suppressing STAT3 signaling (Liu et al., 2018).


Side effects of curcumin range from increased liver enzymes to too much blood thinning when combined with other anti-coagulants.

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