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A Short Summary of Antiaging Interventions

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  A SHORT SUMMARY OF LONGEVITY INTERVENTIONS How to select which intervention to bet on? We’ll look for the following evidence to come up with a strategy: [Longer human lifespan] Drugs/supplements/lifestyle changes that were shown to lower all cause mortality in long-running human RCTs (Randomized Clinical Trials) — the gold standard in research. Additionally, we will consider interventions that are associated with increased human longevity, though the evidence from RCTs might be still emerging.  [Longer mice lifespan with some supporting evidence from humans] Drugs/supplements/lifestyle changes that extended mice lifespan with promising outcomes in short-term human RCTs (~causation) or retrospective analyses (~association).  [Treat based on biomarkers] Treat high/low values in your labs and biomarkers (e.g. optimize when they aren’t in the ideal range).  [Track your N=1] Don’t blindly follow statistics; make sure the drug/supplement you’re taking works for you spe...
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Interferon

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  BACKGROUND ON MPNs: Healthy hematopoietic stem cells are essential for maintaining a robust immune system and overall well-being. These stem cells give rise to various blood cells, including red blood cells, white blood cells, and platelets, which contribute to efficient oxygen transport, protection against infections and malignancies, and proper blood clotting and tissue repair ( 2020 ). In myeloproliferative neoplasms (MPNs), JAK2-pathway overactivation results in the proliferation of an abnormal clone that dominates the bone marrow, outcompeting healthy hematopoietic stem cells. The hyperactivation of JAK2 and excessive production of inflammatory cytokines by MPN cells contribute to chronic inflammation ( 2021 ).  As the cancerous mass increases, the likelihood of acquiring additional mutations also rises, further promoting the disease's progression and exacerbating the decline in healthy stem cell function ( 2010 ). MPNs can be recognized as a disease of accelerated agin...
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