Coffee / Green Coffee Bean Extract
Coffee: In a retrospective analysis, those who drank 4–5 cups of coffee per day had a 12-16% reduced risk of early death in the following 12–13-years. 1 cup per day was associated with a 5–6% lowered risk of early death. In an RCT with 500ml coffee consumption per day, DNA strand breaks in the coffee group decreased in comparison to the control group: − 23% in the coffee group (p = 0.0012). Coffee has the greatest antioxidant capacity among the commonly consumed beverages (>=100mg CGA in a cup). Green coffee bean is rich in chlorogenic acid (CGA) and its related compounds (50% CGA). Increases autophagy across liver, muscle, heart in mice experiments via inhibition of mTOR and global deacetylation of cellular protein. Green Coffee Bean Extract: After 28 days, systolic blood pressure (SBP) in the placebo, 46 mg, 93 mg, and 185mg GCBE groups was reduced by −1.3±3.0 mmHg, −3.2±4.6 mmHg, −4.7±4.5 mmHg, and −5.6±4.2 mmHg from the baseline, respectively. Diasto...