My Longevity Journey

  Histamine and histamine receptor H1 (HRH1) are frequently increased in the tumor microenvironment and induce T cell dysfunction. Mechanistically, HRH1-activated macrophages polarize toward an M2-like immunosuppressive phenotype with increased expression of the immune checkpoint VISTA, rendering T cells dysfunctional. HRH1 knockout or antihistamine treatment reverted macrophage immunosuppression, revitalized T cell cytotoxic function, and restored immunotherapy response .  Allergy, via the histamine-HRH1 axis, facilitated tumor growth and induced immunotherapy resistance in mice and humans. Importantly, cancer patients with low plasma histamine levels had a more than tripled objective response rate to anti-PD-1 (immunotherapy) treatment compared with patients with high plasma histamine. H1 antihistamines were found to induce anti-cancer effects across multiple cell lines ( CLL, HCC, BC, NSCLC, MM, OC, PC…) . Induce cancer-specific, lysosome-dependent cell death and sensitize...

    Exercise significantly reduced the risk of mortality in patients with cancer and in cancer survivors (risk ratio [RR] = 0.76, 95% CI = 0.40-0.93, I2 = 0%, P = .009).   Exercise significantly reduced the risk of recurrence in cancer survivors (RR = 0.52, 95% CI = 0.29-0.92, I2 = 25%, P = .030).  Individuals who reported “any physical activity” were 50% less likely [adjusted hazard ratio (adjusted HR) 0.50, 95% CI 0.27–0.93, p = 0.028] to die of kidney cancer than non-exercisers.   Effect of Exercise on Mortality and Recurrence in Patients With Cancer: A Systematic Review and Meta-Analysis, 2020   Abstract Purpose: Exercise could lower the risk of cancer recurrence and improve mortality, exercise capacity, physical and cardiovascular function, strength, and quality of life in patients with cancer. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to determine the effects of exercise on mortality and recurrence in p...