My Longevity Journey

[ lower HS-CRP, HBP, FBG, HA1C, Insulin, HOMA-IR; extends mice, c elegans lifespan] Effect of Vitamin C Supplementation on Insulin Resistance, β-cell Function and Insulin Sensitivity in Obese and Non Obese Individuals (January 2019) Background: Insulin resistance (IR) is common pathological feature of most of the metabolic disorders including obesity. Vitamin C intake seems useful to counteract obesity and associated complications.  Aim and Objectives: Present research was aimed to study the effect of vitamin C intake on fasting blood glucose, insulin, Homeostatic Model Assessment (HOMA) of Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) and Quantitative Insulin Sensitivity Check Index (QUICKI) in obese and non obese subjects.  Material and Method: Total 80 subjects; (42 centrally obese and 38 non obese) were involved in the present study, they received 500 mg vitamin C 3x a day for 3 months. Results: Significant decrease in fasting blood glucose, serum insulin, HOMA-IR...

Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Cruciferous Vegetables Intake Is Associated with reduced mortality from most cancers.  Consumption significantly increased the urinary excretion of benzene and acrolein. Could increase the detoxification of carcinogens and other xenobiotics in humans.  Cruciferous Vegetables https://lpi.oregonstate.edu/mic/food-beverages/cruciferous-vegetables Cruciferous vegetables could increase the detoxification of carcinogens and other xenobiotics in humans. In this 12-week randomized controlled trial in 391 healthy Chinese adults exposed to high levels of air pollution, daily consumption of a broccoli sprout-rich beverage (providing 600 µmol/day of glucoraphanin and 40 µmol/day of sulforaphane) significantly increased the urinary excretion of a known carcinogen, benzene, and a toxicant, acrolein, compared to placebo (20) .  The biological activities of glucosinolate der...

Green tea consumption was associated with a lower risk of hematologic malignancies including MPNs (HR=0.76).  Shown to suppress JAK2/STAT3 in one study. Strongly inhibited the growth of two RCC cell lines in a concentration-dependent manner, Inhibits growth and induces apoptosis in renal cell carcinoma cells.  Shows antiviral activity.  Extended the lifespan of mice, fruit flies and C elegans, though not every experiment was consistent.  EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression ( link ) Our results suggest that EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression. This is the first report showing that EGCG is likely to be an effective agent for renal cell carcinoma.   Green tea: A promising anticancer agent for renal cell carcinoma Green tea extract strongly inhibited the growth of both RCC cell lines in a concentration-dependent manner, with IC50 values of 54 ± 1...