Green Tea

• Green tea consumption was associated with a lower risk of hematologic malignancies including MPNs (HR=0.76). 

• Shown to suppress JAK2/STAT3 in one study.

• Strongly inhibited the growth of two RCC cell lines in a concentration-dependent manner,

• Inhibits growth and induces apoptosis in renal cell carcinoma cells. 

• Shows antiviral activity. 

• Extended the lifespan of mice, fruit flies and C elegans, though not every experiment was consistent. 

EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression (link)

Our results suggest that EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression. This is the first report showing that EGCG is likely to be an effective agent for renal cell carcinoma.

 

Green tea: A promising anticancer agent for renal cell carcinoma

Green tea extract strongly inhibited the growth of both RCC cell lines in a concentration-dependent manner, with IC50 values of 54 ± 10 and 129 ± 28 μg/ml for A-498 and 769-P cells, respectively.

 

A Review of the Antiviral Role of Green Tea Catechins

EGCG not only suppressed the synthesis of some lytic proteins of EBV but also inhibited the lytic infection. EGC and EGCG showed strong anti-HSV (Herpes Simplex Virus) activity. TGC inhibits Hepatitis B virus. EGCG inhibited the attachment of Adenovirus.  GTC Inhibits HIV. 

 

[NEGATIVE] Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States

The current analysis examined the effect of Green Tea Extract (GTE) consumption on liver injury in 1,021 participants (513 in GTE and 508 in placebo arm) with normal baseline levels of liver enzymes. GTE = 2x2 capsules/day. Per Capsule = 328.8 mg total catechins that included 210.7 mg EGCG, 50.6 mg epicatechin gallate (ECG), 26.7 mg EGC, and 26.8 mg epicatechin (EC). Among women in the GTE arm, alanine aminotransferase (ALT) increased by 5.4 U/L [95% confidence interval (CI), 3.6–7.1] and aspartate aminotransferase increased by 3.8 U/L (95% CI, 2.5–5.1), which were significantly higher than those among women in the placebo arm (both P < 0.001). Overall, 26 (5.1%) women in GTE developed moderate or more severe abnormalities in any liver function measure during the intervention period, yielding an OR of 7.0 (95% CI, 2.4–20.3) for developing liver function abnormalities as compared with those in the placebo arm. ALT returned to normal after dechallenge and increased again after one or more rechallenges with GTE. The rise–fall pattern of liver enzyme values following the challenge–dechallenge cycles of GTE consumption strongly implicates the effect of high-dose GTE on liver enzyme elevations. 

 

Association between green tea consumption and hematological malignancies (link)

41,761 Japanese adults aged 40–79 years without a history of cancer at baseline who answered a food frequency questionnaire survey in 1994. During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. Hazard ratios were calculated by using the Cox proportional hazards regression model. Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms. This inverse association was consistent across sex and body mass index strata. In conclusion, green tea consumption was associated with a lower risk of hematologic malignancies.

 

Matcha green tea prevents obesity-induced hypothalamic inflammation via suppressing the JAK2/STAT3 signaling pathway (link)

Green Tea Polyphenols Extend the Lifespan of Male Drosophila melanogaster While Impairing Reproductive Fitness (link)

Previous reports have found green tea to extend the lifespan of various animal models. In Caenorhabditis elegans, daily administration of 220 μM of EGCG, its most prevalent and active flavonoid, increased the mean lifespan up to 14%.7 This same study showed that under lethal oxidative stress, survival rates increased by 65%.7 However, other groups have determined that despite improved mean longevity under heat and oxidative challenges, EGCG could not extend the lifespan of C. elegans under normal culture conditions.8 In Drosophila melanogaster, flies fed on a diet of green tea extract had an increased mean lifespan of 16% in male flies with a corresponding upregulation of superoxide dismutase (SOD) and catalase.9 Another study reported a 21% increase in male fly lifespan by inhibition of age-related iron accumulation.10 In male C57BL/6 mice, one study reported a longer lifespan in green tea fed mice versus controls (801±121.5 vs. 852.7±88.2 days, P<.05).11 However, reports on heterogeneous mice revealed no differences in lifespan.12,13 A more recent report in Wistar rats revealed that EGCG significantly increased median lifespan to 105 weeks compared with controls at 92.5 weeks.14 These authors found that EGCG delayed death of healthy rats by∼8–12 weeks and attributed the effect to a reduction in age-associated inflammation, oxidative stress, liver and kidney damage.14 In this study, we report that GTPs extend the lifespan of male fruit flies whereas simultaneously reducing male fertility. 

 

Long term consumption of green tea EGCG enhances healthspan and lifespan in mice by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis and immunosenescence (2021)

 

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice, 2012

None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.

 

Examine.com and Paul Lining Institute

https://examine.com/supplements/green-tea-catechins/

https://lpi.oregonstate.edu/mic/food-beverages/tea

 

[Sources: Matcha green tea, green tea]