Cruciferous Vegetables

  • Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro.

  • Cruciferous Vegetables Intake Is Associated with reduced mortality from most cancers. 

  • Consumption significantly increased the urinary excretion of benzene and acrolein. Could increase the detoxification of carcinogens and other xenobiotics in humans. 


Cruciferous Vegetables

https://lpi.oregonstate.edu/mic/food-beverages/cruciferous-vegetables


Cruciferous vegetables could increase the detoxification of carcinogens and other xenobiotics in humans. In this 12-week randomized controlled trial in 391 healthy Chinese adults exposed to high levels of air pollution, daily consumption of a broccoli sprout-rich beverage (providing 600 µmol/day of glucoraphanin and 40 µmol/day of sulforaphane) significantly increased the urinary excretion of a known carcinogen, benzene, and a toxicant, acrolein, compared to placebo (20). 


The biological activities of glucosinolate derivatives, isothiocyanates and indole-3-carbinol, which include modulation of xenobiotic metabolism, but also antioxidant and anti-inflammatory properties, induction of cell cycle arrest and apoptosis, and inhibition of angiogenesis, likely contribute to the potential benefits of cruciferous vegetables in the prevention of cancer (see the MIC articles on Isothiocyanates and Indole-3-Carbinol) (23).




Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro

SFN administration could hold potential for treating RCC patients with established resistance towards everolimus.

 

Sulforaphane as an adjunctive to everolimus counteracts everolimus resistance in renal cancer cell lines.

Adding SFN to an everolimus based RCC treatment regimen in vitro delayed resistance development observed with chronic everolimus monotherapy. Ongoing in vivo studies are necessary to verify the in vitro data.

 

Cruciferous Vegetables Intake Is Associated with Lower Risk of Renal Cell Carcinoma: Evidence from a Meta-Analysis of Observational Studies

We observed a significantly inverse association between CV intake and RCC risk (RR = 0.81, 95% CI [0.72, 0.91]). This association was also significant when analyses were restricted to six high-quality studies (RR = 0.89, 95% CI [0.82, 0.98]).

 

Sulforaphane

Sulforaphane is an anti-cancer compound in cruciferous vegetables, mostly commonly credited to Broccoli. It appears to have general but potent antioxidant and possible anti-inflammatory actions, with the former similar to curcumin.

https://examine.com/supplements/sulforaphane/

 

Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease, & More (link)

 

 

1 cup broccoli sprouts ~ 73mg Sulforaphane

KOYAH EACH JAR - 36 scoops. Each scoop of powder is equivalent to 1/4 cup of fresh organic broccoli sprouts. (18.5mg Sulforaphane / scoop)

Brocco max:

Only 1/4 of 30mg is converted into sulfaraphane (8mg)!

ANTIOXIDANTS For ANTI AGING | How I Use SULFORAPHANE In 2020 (link)

 

Broccoli Sprouts VS Glucoraphanin Supplements | Sulforaphane (link)

 

Best Sulforaphane (Glucoraphanin) Supplement Brands 2020 (link)

 

[Sources of Sulforaphane: Broccoli sprouts, Jarrow Broccomax. It’s easy to grow your own broccoli sprouts, which is the best source of sulforaphane. Regular broccoli and cauliflower also help.]

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